Here's my shield against existential depression, arrived at after much pain (with major influences):

Notice that you don't bother wondering what it all means when you're having fun. Meaning comes from having fun. (http://www.amazon.com/Just-Fun-Story-Accidental-Revolutionar...)

Having fun usually involves work. (http://scrapbook.akkartik.name/post/24169645 http://scrapbook.akkartik.name/post/21256293)

How do you figure out what you love? Do something, see where it leads. Iterate between the doing and the loving as fast as you can. Sketch. (http://scrapbook.akkartik.name/post/24170012 http://scrapbook.akkartik.name/post/24169153 http://scrapbook.akkartik.name/post/1451852)

What you love is a moving target, it changes with you. If you neglect it you will lose it.