Numba is not a general-purpose Python compiler, and does not handle (or intend to handle) many basic Python statements (like class or function definition) at all: http://numba.pydata.org/numba-doc/0.20.0/reference/pysupport...
And most general-purpose Python (e.g. dicts, most builtins, etc...) require running in "object mode" which is not standalone, it calls into the CPython API and thus requires an underlying CPython runtime.
So no, numba is not an other way to do that. shedskin[0] might be though.